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c3ar antagonist sb290157  (MedChemExpress)


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    MedChemExpress c3ar antagonist sb290157
    C3ar Antagonist Sb290157, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 50 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/c3ar+antagonist+sb290157/SB290157/pm41093012-120-4-9
    Average 95 stars, based on 50 article reviews
    c3ar antagonist sb290157 - by Bioz Stars, 2026-10
    95/100 stars

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    Related Articles

    Blocking Assay:

    Article Title: Complement C3/C3a-CCL9 feedback loop orchestrates inflammatory crosstalk to accelerate aortic dissection.
    Article Snippet: .. In designated groups, the C3aR antagonist SB290157 (1 μM; MedChemExpress, HY-101502A, Monmouth Junction, NJ, USA) was added to the upper chamber to block C3aR signaling in macrophages. .. To determine whether CCL9 directly promotes macrophage recruitment, RAW 264.7 cells were seeded in the upper chamber (5 × 105 cells/100 μL per well for 48 h), and the lower chamber contained serum-free medium with or without recombinant mouse CCL9 (20 ng/mL; MedChemExpress, HY-P7772, Monmouth Junction, NJ, USA).

    Infection:

    Article Title: C3a/C3aR Affects the Propagation of Cryptosporidium parvum in the Ileum Tissues of Mice by Regulating the Gut Barrier, Cell Proliferation, and CD4 + T Cell Main Effectors
    Article Snippet: .. Furthermore, a C3aR-inhibited BALB/c suckling mouse model infected with C. parvum was established by intraperitoneally injecting animals with C3aR antagonist SB290157 (MedChemExpress, Princeton, NJ, USA) at a dose of 10 mg/kg before C. parvum infection [ ]. ..

    Injection:

    Article Title: Complement C3a and C3a Receptor Activation Mediates Podocyte Injuries in the Mechanism of Primary Membranous Nephropathy
    Article Snippet: .. The rats in the early-treatment group (n56) were treated with a C3aR antagonist SB290157 (30 mg/kg, HY-101502A; MedChemExpress) from day 0 by daily intraperitoneal injection. ..



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    Necroptotic DPCs release CXCL8 to engage with the neutrophil transmembrane receptor C3AR1 . (A) Three hundred hub genes related to NRDEGs overlapped with genes related to the

    Journal: International Dental Journal

    Article Title: New Insights Into the Correlation Between Necroptotic Activation and Neutrophil Infiltration in Pulpitis

    doi: 10.1016/j.identj.2025.02.016

    Figure Lengend Snippet: Necroptotic DPCs release CXCL8 to engage with the neutrophil transmembrane receptor C3AR1 . (A) Three hundred hub genes related to NRDEGs overlapped with genes related to the "positive regulation of neutrophil chemotaxis" functional entry screening for key molecules in cell communication. (B) STRING site prediction of proteins that interact with C3AR1. (C) WB detection of CXCL8 expression levels in dental pulp (above) and necroptotic DPCs (below). (D) The supernatant of necroptotic DPCs was incubated with neutrophils, and an anti-CXCL8 antibody was used to pull down CXCL8 and C3AR1. Co-IP assay validating the interaction of CXCL8 with C3AR1. (E) C3AR1 inhibitors block DPCs necroptosis and neutrophil chemotaxis.

    Article Snippet: Trifluoroacetate (SB290157, MedChemExpress) acts as a competitive antagonist against C3aR.,

    Techniques: Chemotaxis Assay, Functional Assay, Expressing, Incubation, Co-Immunoprecipitation Assay, Blocking Assay